Endocrine Abstracts

Background: The relationship between energy balance and reproduction is U-shaped, meaning that both a negative and a positive energy balance have a detrimental effect on reproductive function. In a world increasingly burdened by the growing prevalence of obesity, we turned our attention to the negative extremity of weight, by exploring anorexia nervosa (AN) and constitutional thinness (CT) metabolic and reproductive features. Kisspeptin (kiss-1) is a relatively recently discov...

Introduction: Smoking is an independent risk factor for Graves’ disease (GD) and an independent predictor for Graves’ophtalmopathy (GO), but the influence on hyperthyroidism severity was not established.Aim: To evaluate the relationship between smoking and thyroid function at diagnosis and after administration of antithyroid drugs (ATDs) in GD patients.Materials and methods: We prospectively investigated 116 newly diagnos...

Background: Pancreatic neuroendocrine neoplasms (NENs) are rare tumors which can sometimes be diagnosed based on symptoms of hormone excess, but, more often, they are asymptomatic, and patients frequently present with metastatic disease. While they can occur in hereditary cancer syndromes such as multiple endocrine neoplasia type 1 (MEN1), von Hippel-Lindau (VHL), or neurofibromatosis (NF1), the majority of pancreatic NENs are sporadicCase report: We rep...

Introduction: Short stature is a common reason for pediatric endocrine evaluation and it can have a variety of causes, including constitutional, genetic short stature, dysmorphic syndromes, chronic illnesses and also endocrine disorders. Growth hormone deficiency accounts for 8% of the cases and it can be isolated or associated with other pituitary hormones deficiencies, congenital or acquired, such as in central nervous system tumors.Case report: A 15-y...

The aim of our study was to investigate de relationship between anthropometric and body composition parameters and thyroid function (measured with TSH and free T4), as well as thyroid volume, in patients with obesity.Methods: This is a cross-sectional study including patients with obesity consecutively referred to our tertiary endocrine center for diverse pathologies. TSH and free T4 was measured in all patients and thyroid ultrasound was performed by an...

Obesity has been associated with a status of subclinical inflammation. Neutrophil to lymphocyte ratio (NRL) is a widely available and inexpensive inflammatory marker which can be reliable in evaluating the inflammatory status occurring in patients with severe obesity The aim of our study was to investigate the association between NLR and anthropometric and body-composition parameters, in a group of patients with obesityPatients and Methods: 737 patients ...

Introduction: Paragangliomas are neuroendocrine tumors that are derived from the embryonic neural crest cells. Because the paraganglia are widespread through the body, paragangliomas can be found in unusual anatomic locations and the diagnosis can be hard to establish. Case presentationWe present the case of an 72 year-old, hypertensive woman who arrived at the hospital for pain in the right hypochondrium. General examination revealed an abdomen without signs of peritoneal irr...

Introduction: Syndrome of inappropriate secretion of thyrotropin (SITSH) is a rare condition characterized by uninhibited serum TSH in the presence of high thyroid hormones, usually caused by TSH secreting adenoma or resistance to thyroid hormones (RTH). Differential diagnosis between the two is often challenging due to their overlapping features.Case report: We present the case of a 50-year-old postmenopausal woman with a history of -myocardial infarcti...

Introduction: Functioning gonadotroph adenomas (FGA) are adenomas secreting and expressing biologically active gonadotropins and causing distinct clinical manifestations. The vast majority of the immunohistochemically confirmed gonadotroph adenomas are hormonally silent (presenting only with mass effects), clinically FGA’s being very rare; whereas their exact prevalence is not known.Case study: A 46 years old male patient presents to our clinic afte...

Background: Chromogranin A (CgA) belongs to the family of granins, proteins which are an integral part of the secretory granules of neuroendocrine cells in endocrine glands and the diffuse neuroendocrine system. While it has become standard clinical practice to measure serum CgA in neuroendocrine tumors, various other non-endocrine conditions may increase this marker’s concentration and lead to diagnostic problems.Case report: We present the case of...